Final answer:
The diagnosis for the 50-year-old man is chronic myeloid leukemia (CML).
Step-by-step explanation:
The diagnosis for the 50-year-old man presenting with early satiety, splenomegaly, and bleeding, along with the cytogenetics showing t(9,22), is chronic myeloid leukemia (CML). CML is a type of cancer that affects the bone marrow and blood cells. The translocation of chromosomes 9 and 22, known as the Philadelphia chromosome, is a characteristic feature of CML.