Final answer:
The property that is determined by the arrangement of atoms in a substance is Atomic Structure.
Step-by-step explanation:
The property that is determined by the arrangement of atoms in a substance is Atomic Structure. The arrangement of atoms in a substance determines its chemical and physical properties, such as its reactivity, conductivity, and melting point. The arrangement of atoms also affects the bonding between atoms and the overall structure of the substance. For example, the arrangement of carbon and hydrogen atoms in a diamond results in a hard, transparent crystal structure, while the arrangement of carbon atoms in graphite results in a soft, black structure. Therefore, the arrangement of atoms plays a crucial role in determining the properties of a substance.