Final answer:
Sickle-cell anemia is a genetic condition characterized by abnormally shaped red blood cells that can cause clotting and impaired circulation, reducing oxygen perfusion into the blood.
Step-by-step explanation:
Sickle-cell anemia is a genetic condition characterized by abnormally shaped red blood cells that take on a crescent-like or sickle shape. These abnormal cells can get stuck in narrow blood vessels, leading to clotting and impaired circulation. This condition reduces the oxygen perfusion into the blood and can cause a variety of serious problems.