Final answer:
Methyldopa is the medication associated with the production of autoantibodies to JKa, which can cause complications such as hemolytic anemia in patients.
Step-by-step explanation:
Autoantibodies to JKa have been found in patients taking certain medications. Among the listed options, Methyldopa, a medication used to treat high blood pressure, has been associated with the production of autoantibodies, including those to JKa, a blood group antigen. Penicillin, another option mentioned, can also induce autoantibodies, but these are less commonly associated with the anti-JKa antibody formation. However, Methyldopa is the medication most commonly linked to this autoimmune response. Therefore, in patients taking Methyldopa, monitoring for the development of these antibodies may be indicated, as they can cause complications such as hemolytic anemia.