Question

What is the mechanism of action of non-beta-lactam antibacterial medication in cell wall (peptidoglycan) synthesis?

1) Inhibition of transpeptidase enzyme
2) Inhibition of penicillin-binding proteins
3) Inhibition of peptidoglycan cross-linking
4) Inhibition of cell wall synthesis

Answer 1

Non-beta-lactam antibacterial medications inhibit cell wall synthesis in bacteria by interfering with the formation of peptide crosslinks.

Step-by-step explanation:

Non-beta-lactam antibacterial medications inhibit cell wall synthesis in bacteria, making them more susceptible to osmotic lysis. This mechanism of action is bactericidal and selectively targets bacteria without affecting human cells. Specifically, these medications interfere with the formation of peptide crosslinks in the peptidoglycan layer of the cell wall. Examples of non-beta-lactam antibacterial medications include vancomycin and penicillins.