Final answer:
GI prophylaxis (ppx) refers to the use of medications to reduce the risk of aspiration during certain medical procedures or in individuals at high risk. The evidence behind GI ppx for aspiration comes from various studies and clinical trials. Studies have shown the effectiveness of GI ppx in preventing aspiration.
Step-by-step explanation:
Aspiration is the inhalation of foreign material into the airways and lungs, and can lead to serious complications such as pneumonia. Gastrointestinal (GI) prophylaxis (ppx) refers to the use of medications to reduce the risk of aspiration during certain medical procedures or in individuals at high risk.
The evidence behind GI ppx for aspiration comes from various studies and clinical trials. For example, a study published in the European Journal of Pharmaceutical Sciences compared two software programs, GASTROPLUSTM and IDEA TM, which are used to predict intestinal absorption. The study found that GASTROPLUSTM had better predictive performance for the absorption of compounds.
Other studies have shown the effectiveness of GI ppx in preventing aspiration. For instance, a randomized controlled trial published in the New England Journal of Medicine found that the use of acid suppressive therapy reduced the incidence of aspiration pneumonia in critically ill patients.