Final answer:
The best drug to break an SVT secondary to antidromic conduction is Adenosine.
Step-by-step explanation:
The best drug to break an SVT secondary to antidromic conduction is Adenosine (option 1).
Adenosine is commonly used in the acute setting to terminate SVT. It works by activating adenosine receptors, which inhibit the conduction of electrical impulses through the AV node, effectively breaking the reentrant circuit responsible for SVT.
Amiodarone (option 2), verapamil (option 3), and digoxin (option 4) are also used to treat various cardiac dysrhythmias, but they are not typically the first-line choice for breaking SVT.