Question

A client on antidepressant therapy develops hyponatremia. Which drug may be responsible for the client's electrolyte imbalance?

1) Phenelzine
2) Paroxetine
3) Imipramine
4) Amitriptyline

Answer 1

Paroxetine, a selective serotonin reuptake inhibitor (SSRI), may be responsible for a client's development of hyponatremia while on antidepressant therapy.

Step-by-step explanation:

Hyponatremia, which is an electrolyte imbalance characterized by low sodium levels in the blood, can be caused by certain antidepressant drugs. From the options given, the drug most likely responsible for the client's hyponatremia is paroxetine (Option 2).

Paroxetine is a selective serotonin reuptake inhibitor (SSRI), a class of antidepressant medications that work by blocking the reuptake of serotonin in the brain, thereby increasing its levels. While SSRIs generally have fewer anticholinergic side effects, they can occasionally cause hyponatremia, especially in older adults or individuals taking other medications that affect serotonergic systems.

It is important for the client to consult their healthcare provider if they experience any symptoms of hyponatremia, such as confusion, headache, nausea, seizures, or muscle weakness.