Question

What type of plasma donor has the highest risk of causing TRALI in the recipient?

1) Male donors
2) Female donors
3) Donors with a history of smoking
4) Donors with a history of drug use

Answer 1

Female donors have the highest risk of causing TRALI in the recipient due to specific antibodies associated with TRALI.

Step-by-step explanation:

The type of plasma donor that has the highest risk of causing TRALI (Transfusion-Related Acute Lung Injury) in the recipient is female donors. TRALI is a serious condition characterized by sudden respiratory distress after receiving a blood transfusion. Research suggests that female donors, especially those who have been previously pregnant, have higher levels of antibodies associated with TRALI. These antibodies can react with certain components in the recipient's blood, triggering an immune response that leads to lung injury.