Final answer:
Gilbert's syndrome is a genetic disorder of bilirubin metabolism. Its two aspects are the defect in UDP-glucuronyl transferase activity in the liver and the clinical considerations, including mild jaundice.
Step-by-step explanation:
Gilbert's Syndrome
Gilbert's syndrome is a genetic disorder of bilirubin metabolism, affecting about 5% of the population. It is characterized by a defect in the uptake of bilirubin by the liver due to lowered UDP-glucuronyl transferase activity.
Defect
The defect in Gilbert's syndrome is a lowered UDP-glucuronyl transferase activity, which impairs the liver's ability to uptake and process bilirubin effectively.
Clinical Considerations
In terms of clinical considerations, individuals with Gilbert's syndrome may have elevated levels of unconjugated bilirubin in their bloodstream, which can lead to a condition called hyperbilirubinemia. This may result in mild jaundice, especially during periods of stress, fasting, or illness.