Final answer:
The dosage of a drug must be carefully determined to achieve therapeutic levels without causing side effects. Factors to consider include patient's mass and liver or kidney dysfunction.
Step-by-step explanation:
Dosage and Route of Administration:
The dosage of a drug must be determined carefully to achieve therapeutic drug levels without causing significant side effects. Factors to consider include the patient's mass, as it affects dosing in children but not in adults and children aged 12 and older. Patients with liver or kidney dysfunction may have reduced drug metabolism or clearance, leading to increased drug levels and higher risk of toxicity and side effects.