Final answer:
Loss of compliance in vasculature, such as in arteriosclerosis, leads to increased resistance and pressure in the vessels, resulting in hypertension and coronary heart disease. The heart has to work harder to overcome this resistance and maintain blood flow.
Step-by-step explanation:
Loss of compliance in vasculature occurs in conditions like arteriosclerosis, where the arteries become stiff and less able to expand to accommodate increased blood flow. This reduction in compliance leads to increased resistance and pressure within the vessels and can cause hypertension and coronary heart disease. Physiologically, the heart has to work harder to generate enough pressure to overcome this resistance and maintain blood flow.