Question

Blood levels of which of the following analytes rise within 4 hours after an acute myocardial infarction?

1) Troponin I
2) Creatine kinase-MB
3) Myoglobin
4) Lactate dehydrogenase

Answer 1

Myoglobin and creatine kinase-MB rise within 4 hours after an acute myocardial infarction. Troponin I rises within 3-12 hours, and lactate dehydrogenase peaks around 6 days after the incident.

Step-by-step explanation:

Among the analytes listed, myoglobin and creatine kinase-MB (CK-MB) are known to rise within 4 hours after an acute myocardial infarction (MI). Myoglobin is one of the earliest markers to increase following an MI. CK-MB is also an early marker and is known as the traditional marker enzyme for diagnosing a myocardial infarction, as it is the first enzyme to increase within a short time in the blood plasma after a heart attack. While troponin I is a highly sensitive and specific marker for myocardial infarction, its levels in blood typically rise within 3-12 hours after the onset of chest pain, reaching peak values in 24-48 hours. Lactate dehydrogenase (LDH) is another enzyme that is released into the blood during tissue damage; however, LDH levels tend to rise later and peak around 6 days following the attack.