Question

What factors affect systemic toxicity of local anesthetics?

Answer 1

Factors that affect the systemic toxicity of local anesthetics include concentration, dosage, route of administration, and metabolism.

Step-by-step explanation:

Factors that affect the systemic toxicity of local anesthetics include:

1. Concentration: Higher concentrations of local anesthetics can increase the risk of systemic toxicity.
2. Dosage: Higher dosages of local anesthetics can increase the risk of systemic toxicity.
3. Route of administration: Intravenous administration of local anesthetics carries a higher risk of systemic toxicity compared to other routes such as topical or local infiltration.
4. Metabolism: The metabolism of local anesthetics can affect their systemic toxicity. Some individuals may metabolize certain anesthetics slower or faster, leading to differences in toxicity.

These factors should be carefully considered when administering local anesthetics to minimize the risk of systemic toxicity.