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Which of the following options are related to the causes of increased ventilatory drive?

1) hypoxic ventilatory decline
2) relationship between effects of PaCO₂ and PaO2 on the carotid body
3) other causes of inc. ventilatory drive

User Yariv Bar
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Final answer:

Increased ventilatory drive can be caused by decreased blood pH, increased carbon dioxide levels, and increased exercise, all of which stimulate various receptors and centers that control breathing to maintain the body's acid-base balance.

Step-by-step explanation:

The causes of increased ventilatory drive are related to the need for the body to maintain homeostasis in face of various physiological demands. Hyperventilation, one of the ways ventilatory drive can increase, occurs when there is an excessive rate of ventilation, leading to low levels of blood carbon dioxide and high pH, a condition also referred to as respiratory alkalosis. Factors that influence increased ventilatory drive include:

  • Decreased blood pH: A lower pH level indicates increased acidity in the blood, often due to the accumulation of carbon dioxide and metabolic byproducts like lactic acid, which stimulate chemoreceptors in the carotid body and aortic arch to increase ventilation.
  • Increased carbon dioxide: Elevated levels of CO2 in the blood, known as hypercapnia, directly affect the central chemoreceptors in the medulla oblongata, causing an increase in the depth and rate of breathing.
  • Increased exercise: Exercise induces hyperpnea, which is an increase in the rate and depth of breathing, activated by neural mechanisms including motor neuron activation and proprioceptor stimulation based on the demand for more oxygen and the need for removal of CO2.

Together, these factors ensure that oxygen and carbon dioxide levels are tightly regulated, maintaining the essential acid-base balance in the body.

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