Final answer:
During a scene size-up at a motor vehicle crash, the first element that should be assessed is the possible hazards to your safety.
Step-by-step explanation:
The element that should be assessed first during a scene size-up at a large motor vehicle crash scene is possible hazards to your safety. It is important to ensure your own safety before attending to others. Assessing the scene for hazards such as leaking fuel, live electrical wires, or unstable structures will help prevent further injuries to yourself and others.