Final answer:
Gallstones are the cause of RUQ pain with high bilirubin and alkaline phosphatase levels.
Step-by-step explanation:
The cause of RUQ pain with high bilirubin and alkaline phosphatase levels is 1) gallstones.
Gallstones can cause obstruction in the flow of bile in the bile ducts, leading to an increase in conjugated bilirubin in the blood. This can result in jaundice, which manifests as yellowing of the skin and whites of the eyes. Additionally, gallstones can block the bile duct and cause pain in the right upper quadrant of the abdomen.