Final answer:
Tricyclic antidepressants (TCAs) inhibit the reuptake of norepinephrine, serotonin, and/or dopamine, which increases the levels of these neurotransmitters in the synaptic cleft.
Step-by-step explanation:
Tricyclic antidepressants (TCAs) inhibit the reuptake of norepinephrine, serotonin, and/or dopamine, which increases the levels of these neurotransmitters in the synaptic cleft. They do not inhibit the enzyme monoamine oxidase nor block cholinergic synapses, but instead work by blocking the active sites of three specific serotonin receptors.