Final answer:
Epinephrine 1 mg should be given first by the IV/IO route when a patient is in cardiac arrest and ventricular fibrillation is refractory to a second shock.
Step-by-step explanation:
In a situation where a patient is in cardiac arrest and ventricular fibrillation is refractory to a second shock, the first drug that should be given by the IV/IO route is epinephrine 1 mg.
Epinephrine is a vasoconstrictor that increases blood flow to the heart and brain, and it can help restore a normal heartbeat. It is typically administered every 3-5 minutes during cardiac arrest resuscitation.
Amiodarone, lidocaine, and atropine are used for other cardiac arrhythmias but are not the first-line drugs for treating ventricular fibrillation in this scenario.