Final answer:
When a patient with possible ACS has chest pain and is unresponsive to nitro sublingual x3, and experiences increased chest pain and low blood pressure after the administration of morphine, it is best to administer oxygen.
Step-by-step explanation:
When a patient with possible ACS has chest pain and is unresponsive to nitro sublingual x3, and subsequently experiences increased chest pain and low blood pressure after the administration of morphine, it is important to take immediate action. In this scenario, the best course of action would be to administer oxygen to the patient. Supplemental oxygen helps to increase the oxygen supply to the heart and can alleviate symptoms of ischemia. Administering another dose of nitro sublingual may not be effective if the patient has already shown no response to previous doses. Administering aspirin or an IV fluid bolus may not directly address the immediate issue of increased chest pain and low blood pressure.