Final answer:
The next step in management for a patient in refractory ventricular fibrillation would be to administer a second dose of amiodarone.
Step-by-step explanation:
The next step in management for a patient in refractory ventricular fibrillation after receiving multiple appropriate defibrillation shocks, 1mg of epinephrine twice, and an initial 300mg of amiodarone intravenously, would be to administer a second dose of amiodarone.