Final answer:
The clinic nurse should be most concerned about the symptom of difficulty tying shoes due to the potential for it to indicate peripheral neuropathy, a serious side effect of isoniazid.
Step-by-step explanation:
The clinic nurse should be most concerned about the client's complaint of difficulty tying shoes when assessing a client who has been on isoniazid for 6 months. This symptom may indicate peripheral neuropathy, a known side effect of isoniazid therapy, which can impact motor coordination and fine motor skills. Dry mouth, cramping diarrhea, and frequent headaches, while they can be side effects of the medication or symptoms of other conditions, are not typically as concerning as difficulty with motor coordination, which could signify nerve damage.
It is important for the nurse to assess this symptom further and consult with the healthcare provider as it may require adjusting the treatment regimen or adding a B6 supplement to prevent further nerve damage. Peripheral neuropathy can become severe and potentially irreversible if not addressed promptly.