Question

Oligomycin is an antibiotic that binds ATP synthase, blocking the flow of protons through the enzyme's proton channel. In addition to preventing synthesis of ATP, what additional effect might you expect in response to the presence of oligomycin?

A. a buildup of protons in the mitochondrial matrix
B. higher pH in the intermembrane space
C. lower pH in the intermembrane space

Answer 1

Oligomycin binding to ATP synthase blocks the flow of protons, leading to a lower pH in the intermembrane space.

Step-by-step explanation:

When oligomycin binds to ATP synthase, it blocks the flow of protons through the enzyme's proton channel. This prevents the synthesis of ATP. However, the flow of electrons through the electron transport chain continues, creating a buildup of protons in the intermembrane space. This causes the intermembrane space to become more acidic, resulting in a lower pH. So, the correct option is C. lower pH in the intermembrane space.