Question

Prednisone is a glucocorticoid. While it reduces inflammation, given overtime it leads to a weakening of tissue, most notable is bone loss and bone strength. A grade 3 mob could cause worse damage as a result so much caution must be taken. What is the most notable effect of prednisone on tissue?

1) Muscle loss
2) Skin thinning
3) Bone loss
4) Joint stiffness

Answer 1

The most notable effect of prednisone on tissue is bone loss. This condition, osteoporosis, brings about decreased bone density and enhanced fracture risk, particularly with long-term use of prednisone.

Step-by-step explanation:

The most notable effect of prednisone on tissue is bone loss. Prednisone is a synthetic glucocorticoid that mirrors the effects of cortisol in reducing inflammation and suppressing the immune system. Along with managing conditions such as asthma and arthritis, prolonged use of prednisone can lead to osteoporosis, a condition characterized by a reduction in bone tissue density and an increase in fracture risk. Factors such as poor diet, lack of exercise, and other environmental influences can exacerbate bone loss. In conditions like Cushing syndrome, where there is an overproduction of cortisol, patients may experience bone pain and weakening of the bones due to increased protein breakdown for gluconeogenesis. Consequently, treatments for such disorders aim to regulate cortisol levels to prevent further tissue weakening.

Therefore, when considering the answer options provided, number 3) Bone loss is the correct answer as the most notable effect of prednisone on tissue.