Final answer:
Cough and breathing difficulty in children with sickle cell disease can indicate complications such as acute chest syndrome or a lung infection.
Step-by-step explanation:
Cough and breathing difficulty in children with sickle cell disease can indicate certain complications related to the respiratory system. One common complication is acute chest syndrome, which is characterized by inflammation and blockage of the small blood vessels in the lungs. This can lead to symptoms such as coughing, shortness of breath, and chest pain. Another possible cause is a lung infection, such as pneumonia, which can also result in cough and breathing difficulties.