Final answer:
21-OH hydroxylase deficiency in newborns can present as congenital adrenal hyperplasia with symptoms such as salt-wasting and ambiguous genitalia.
Step-by-step explanation:
21-OH hydroxylase deficiency is a genetic disorder that affects the production of certain hormones in the adrenal glands. In newborns, this deficiency can present as a condition called congenital adrenal hyperplasia (CAH). The symptoms of CAH can vary depending on the severity of the deficiency, but they may include salt-wasting, ambiguous genitalia in females, and adrenal crisis. For example, a newborn with 21-OH hydroxylase deficiency may have low levels of cortisol and aldosterone, which can lead to dehydration, poor feeding, and electrolyte imbalances.