Final answer:
Increased goblet cell size contributes to the production of mucus associated with chronic bronchitis.
Step-by-step explanation:
The factor that contributes to the production of mucus associated with chronic bronchitis is increased goblet cell size. Goblet cells are specialized cells in the respiratory tract that produce and secrete mucus. In chronic bronchitis, the goblet cells increase in size and produce excessive mucus, which leads to the characteristic symptoms of chronic bronchitis including coughing and difficulty breathing.