Final answer:
The nurse should caution the patient against combining acetaminophen with alcohol to prevent liver damage.
Step-by-step explanation:
When instructing a patient requiring long-term acetaminophen use, the nurse should advise caution against combining acetaminophen with alcohol. This is because using acetaminophen while drinking alcohol can increase the risk of liver damage. It is important to note that acetaminophen does not increase the risk of bleeding, so option 2 can be eliminated. Taking acetaminophen with meals is not necessary to prevent gastric irritation, so option 3 is incorrect. Lastly, physical dependence does not occur with long-term oral use of acetaminophen, making option 4 incorrect.