Final answer:
President Theodore Roosevelt differed from his predecessors in his Progressive economic policies and proactive foreign policy approach, advocating for social reforms domestically and engaging in varied strategic interactions internationally.
Step-by-step explanation:
Two important differences between President Theodore Roosevelt and the previous three presidents were his economic policies and foreign policy approach. Unlike his predecessors, Roosevelt was an ardent supporter of Progressive reforms, advocating for women's suffrage, a system of social insurance, federal welfare programs, and the regulation of corporations. This represented a shift towards the left in American politics and a break from conservative interests that previously dominated the Republican Party.
Furthermore, Roosevelt's foreign policy was marked by his proactive approach in Latin America and Asia, employing different strategies tailored to each region which distinguished him from prior administrations. His focus on the Progressive spirit and his confrontations with big business set an agenda which influenced successors like Taft and Wilson, despite differences in execution.