Question

What diagnostic testing should be done prior to administering AzatHIOprine for Connective Tissue Disorders?

1) Complete blood count (CBC)
2) Liver function tests
3) THIOpurine methyltransferase (TPMT) genotype testing
4) All of the above

Answer 1

Prior to administering Azathioprine for Connective Tissue Disorders, diagnostic tests such as complete blood count, liver function tests, and TPMT genotype testing should be done.

Step-by-step explanation:

Prior to administering Azathioprine for Connective Tissue Disorders, several diagnostic tests should be done to ensure patient safety and determine the appropriate dosage. These tests include:

1. Complete blood count (CBC): This test measures levels of different blood cells, such as white blood cells and platelets, which can indicate any abnormalities or potential side effects of the medication.
2. Liver function tests: These tests measure levels of enzymes and other substances in the blood that indicate how well the liver is functioning. Azathioprine can affect liver function, so these tests are important to monitor any potential liver damage.
3. THIOpurine methyltransferase (TPMT) genotype testing: TPMT is an enzyme that plays a role in how the body metabolizes Azathioprine. Genetic testing can determine if a patient has variations in the TPMT gene that may affect their response to the medication.

Therefore, the correct answer is 4) All of the above.