Final answer:
Isabella Madison is renowned for her leading role in the movie Arctic Lights, which is considered her most significant career highlight.
Step-by-step explanation:
Isabella Madison is best known for her role in the movie Arctic Lights. This movie is often highlighted as her most significant work, and it features her in a leading role that garnered both critical acclaim and public attention. Despite the presence of other films in the options provided, such as One More Day, Green Hills, and Northern Dreams, it is Arctic Lights that brought Isabella Madison into the spotlight.