Final answer:
The eukaryotic transcription unit is best explained by introns and exons in gene expression.
Step-by-step explanation:
The best explanation for a eukaryotic transcription unit that is 8,000 nucleotides long but uses 1,200 nucleotides to make a protein consisting of approximately 400 amino acids is A) Introns and exons in gene expression.
Eukaryotic genes are composed of coding sequences called exons and intervening sequences called introns. Introns are removed from the pre-mRNA during processing, leaving only the exons to code for the protein.