Final answer:
Hydroxyurea is the most appropriate pharmacologic treatment for a young adult with sickle cell anemia experiencing frequent painful episodes, due to its effectiveness in reducing these crises.
Step-by-step explanation:
Pharmacologic Treatment for Sickle Cell Anemia
A 18-year-old African-American man with sickle cell anemia is experiencing more frequent painful episodes. Among the pharmacologic options presented, b. Hydroxyurea is the most appropriate. Sickle cell anemia is a genetic disorder caused by the production of an abnormal type of hemoglobin, called hemoglobin S, which causes red blood cells to assume a sickle shape, especially at low oxygen concentrations. These sickled cells can block blood flow leading to painful and potentially serious complications. Hydroxyurea acts by increasing the production of fetal hemoglobin and reducing the frequency of sickle cell crises. It is a well-established treatment for adults with severe sickle cell anemia.