Final answer:
The three major issues of Andrew Jackson's administration were Indian removal, tariffs, and banking policies. Slavery, though significant, was not one of the three defining issues of his presidency. Jackson took actions that resulted in Indian removal, adjusted tariff rates, and targeted the Second Bank of the United States.
Step-by-step explanation:
The three major issues that dominated Andrew Jackson’s administration were related to the nation's rapid geographic and expansion and economic growth. These issues were Indian removal, concerns over the tariff and nullification, and the future of the Second Bank of the United States (BUS). Jackson was known for enforcing the Indian Removal Act, which led to the displacement of the Native American tribes, often referred to as the Five Civilized Tribes, from the Southeast. He also worked to both lower the tariff rates that were controversially high in the Tariffs of 1828 and 1832 and took a strong stance in the Nullification Crisis with South Carolina to preserve the union. Furthermore, he believed in a strict construction of the Constitution and thus targeted the Second Bank of the United States, seeing it as an overreach of federal power. Slavery, while a divisive issue during Jackson's time and one that would contribute to the eventual American Civil War, was not one of the three defining issues of Jackson’s administration as highlighted in the provided references.