Final answer:
The Centers for Disease Control and Prevention (CDC) established universal precautions and body substance isolation rules.
Step-by-step explanation:
The organization responsible for establishing universal precautions and body substance isolation rules is the Centers for Disease Control and Prevention (CDC). These guidelines were implemented to prevent the transmission of infections and provide a standard of practice for the handling of potentially infectious materials in healthcare settings. The CDC, an agency of the Department of Health and Human Services, plays a crucial role in setting and overseeing such infection control protocols to protect the public from disease and injury.