Final answer:
Androgen Insensitivity Syndrome (AIS) (option A) is the condition not detected until puberty in XY males, characterized by unresponsiveness to androgens due to a mutated Androgen Receptor gene, causing a female appearance despite male chromosomes.
Step-by-step explanation:
The condition that is not detected until puberty for XY males is Androgen Insensitivity Syndrome (AIS). In AIS, individuals have an XY chromosome configuration but due to a mutation in the Androgen Receptor (AR) gene on the X chromosome, their bodies do not respond to androgens like testosterone. As a result, these individuals have male chromosomes but are resistant to male hormones, often leading to a female appearance. It is usually recognized at puberty when, despite having testes, the individual does not develop typical male secondary sexual characteristics.
For reference, the XXY genotype is associated with Klinefelter syndrome, which is another condition that affects male individuals, leading to small testes, enlarged breasts, and reduced body hair. Turner syndrome, with an XO genotype, affects female individuals, resulting in short stature and sterility.