Question

A structure-activity-relationship study considers:

A. The relationship of many enzymes based upon both their structure and activity.
B. Examines the structure of an enzyme then compares it to its activity with the drug.
C. Makes a series of small structural changes to the drug then compares it to its activity with the enzyme.
D. Isolates small portions of the protein to examine how their structure relates to their activity.

Answer 1

The structure-activity-relationship (SAR) study involves making small structural changes to a drug and comparing its activity with the target enzyme. By modifying the drug's structure, scientists can understand how different structural features affect its activity and effectiveness. This knowledge can help improve the drug's stability, potency, and selectivity.

Step-by-step explanation:

The structure-activity-relationship (SAR) study in biology refers to making a series of small structural changes to a drug and comparing its activity with the target enzyme. By modifying the structure of the drug, scientists can understand how different structural features affect the drug's activity and effectiveness. This knowledge can then be used to improve the drug's stability, potency, and selectivity.

For example, through amino acid scans, truncations, and N- and C-terminal modifications, researchers can determine the importance of specific amino acid side chains and sequences in the drug. They can also identify essential residues and structural features required for the drug's biological activity.