Question

The accompanying hypothetical pedigree is for a family where some members have symptoms of Leigh syndrome, which is caused by an mtDNA mutation that reduces ATPase. Of the following, who in the youngest generation might transmit the condition in the future?

A) Any of the members of this generation
B) Any of the women
C) Any of those affected
D) Any of the affected women
E) Only those with an affected mother

Answer 1

In Leigh syndrome, the condition can be transmitted by any member of the youngest generation, but it is most likely to be transmitted e. if the affected individual has an affected mother.

Step-by-step explanation:

e. In the case of Leigh syndrome, which is caused by an mtDNA mutation that reduces ATPase, the condition can be transmitted by any member of the youngest generation (the affected individuals).

However, the most likely scenario for future transmission is if the affected individual has an affected mother. This is because Leigh syndrome is typically inherited maternally due to the presence of the mtDNA mutation in the mother's egg cells.