Final answer:
The Battle of Santiago took place in the Caribbean during the Spanish-American War, where the U.S. Navy defeated the Spanish fleet and secured control over the region.
Step-by-step explanation:
The accurate statement concerning the Battle of Santiago during the Spanish-American War is that the battle took place in the Caribbean. The U.S. Navy was able to defeat the Spanish fleet outside of the port of Santiago de Cuba, which had attempted to escape the U.S. naval blockade. This resulted in every Spanish vessel being sunk. The Spanish army in Santiago de Cuba surrendered within two weeks, leading to an end of the major fighting on the island. American forces subsequently successfully invaded Puerto Rico, which was the last Spanish colony in the region. This allowed the United States to establish control over the Caribbean, and it significantly contributed to the eventual victory in the war.