Question

What are some examples of Primary B Cell/Antibody Deficiencies?

a) DiGeorge syndrome
b) Hyper-IgM syndrome
c) Ataxia-telangiectasia
d) Chronic granulomatous disease

Answer 1

Primary B cell/antibody deficiencies are caused by genetic abnormalities and can result in a lack of production of specific antibodies. Examples include X-linked agammaglobulinemia, Severe Combined Immunodeficiency, and Selective IgA Deficiency. The option (B) is correct.

Step-by-step explanation:

Primary B cell/antibody deficiencies are caused by genetic abnormalities and can result in a lack of production of antibodies. Some examples of primary B cell/antibody deficiencies include:

1. X-Linked Agammaglobulinemia (XLA): This condition is characterized by a defective gene called BTK, which leads to a halt in B cell maturation and differentiation, resulting in a lack of immunoglobulin production.
2. Severe Combined Immunodeficiency (SCID): This is a genetic disorder that interferes with normal B cell and T cell production, leaving individuals extremely vulnerable to infectious diseases.
3. Selective IgA Deficiency: This is the most common inherited form of immunoglobulin deficiency, where individuals are unable to produce secretory IgA, predisposing them to lung and gastrointestinal infections.

These examples demonstrate how genetic abnormalities can lead to primary B cell/antibody deficiencies and impair the immune system's ability to produce specific antibodies. Therefore, option (B) is correct.