Final answer:
Sexual intercourse must be timed closely with ovulation to optimize the chances of fertilization, due to the survival rates of both sperm and the egg, and the process of capacitation that the sperm must undergo in the female reproductive tract.
Step-by-step explanation:
For fertilization to take place, sexual intercourse needs to be timed with ovulation because this is when the conditions are optimal for egg fertilization. Ovulation occurs around the midpoint of a menstrual cycle, generally on day 14 of a 28-day cycle, wherein the egg is released and travels into the fallopian tube. Sperm need to be present in the fallopian tube for fertilization to occur. Since sperm can survive for 3-5 days in the reproductive tract but an egg only survives for about 24 hours after being released, the best chance for fertilization occurs when intercourse takes place within a window of two days before and up to one day after ovulation.
The endometrial lining also undergoes changes to help sperm reach the oocyte, such as becoming more vascular and the cervical mucus becoming thinner. These changes increase the chances of sperm surviving the harsh conditions of the female reproductive tract and reaching the oocyte.
Capacitation is a crucial process that sperm must undergo, which improves their motility and ability to penetrate the oocyte. This process is facilitated by the fluids in the female reproductive tract that prime the sperm, thinning their membrane for better enzyme release necessary to penetrate the egg. Once fertilization occurs, the newly formed zygote (the fertilized ovum) will become resistant to penetration by any other sperm.