Final answer:
The nurse should instruct a client on raloxifene therapy to watch for signs of Deep vein thrombosis (DVT), such as pain, swelling, and redness in a leg, as it is a known adverse reaction.
Step-by-step explanation:
When teaching a client about raloxifene therapy to prevent osteoporosis, the nurse should instruct the client to monitor for several adverse reactions. One adverse reaction to be particularly vigilant about is Deep vein thrombosis (DVT). Raloxifene is a selective estrogen receptor modulator (SERM) which mimics some effects of estrogen in the body. While raloxifene can help maintain bone density and reduce the risk of osteoporosis, it also carries a risk of blood clots, similar to other forms of hormone therapy. Clients should be informed about the signs and symptoms of DVT, which can include pain, swelling, and redness in a leg.