Final answer:
The early signs of smallpox include high fever, body aches, and headaches, but not skin blisters, which appear in a later stage of the disease.
Step-by-step explanation:
The early signs and symptoms of smallpox include a variety of telltale physical symptoms, but there is one option listed that is not typically associated with the initial presentation of smallpox. The early signs of smallpox include high fever, body aches, and headaches. However, skin blisters are not an early sign of smallpox; they appear at a later stage of the disease. Smallpox symptoms typically start with a high fever, fatigue, and head and body aches, followed by the development of a characteristic rash that progresses to raised bumps and then to fluid-filled blisters.