Final answer:
True, Isaiah ministered in the southern kingdom of Judah which remained after the split of the united monarchy of Israel following Solomon's reign.
Step-by-step explanation:
The statement that Isaiah ministered in the southern two tribes known as Judah is true. After the death of Solomon, the kingdom of Israel split into two: the northern kingdom, known as Israel, and the southern kingdom, known as Judah. Isaiah was one of the prophets in Judah during the time of the divided monarchy. He, like other prophets of Judah, likely interpreted the challenges and disasters that befell Israel and later Judah as divine punishment for straying from the covenant with Yahweh. While the northern kingdom was eventually destroyed by the Assyrian Empire, Judah initially avoided this fate and maintained its distinct identity, which included the worship of Yahweh, the god after whom the people of Judah—Jews—were named.
Throughout this period, the prophets played a critical role in calling for religious reforms and adherence to the belief in Yahweh as the central deity, especially in the face of external threats and internal challenges, including the spread of polytheistic practices. The ministry of Isaiah specifically addressed the need for Judah to maintain its covenantal faith to avoid the destruction that befell Israel.