Question

36 y/o had right thigh pain after she bumped into a table. The area became very swollen and tender. Exam showed scattered bruises over her trunk and lower legs. She never had such similar issues and no known fam hx of bleeding disorders. She has normal PT and prolonged PTT. Ddx:

1. impaired synthesis of coagulation factor
2. presence of coag factor inhibitor
3. endothelial dysfunction

Answer 1

The most likely differential diagnosis (DDx) for the patient's symptoms is the presence of a coagulation factor inhibitor. This means that the person's blood contains an inhibitor that is preventing normal blood clotting. Further medical consultation is advised for proper diagnosis and treatment.

Step-by-step explanation:

The symptoms described in the question suggest a possible bleeding disorder. Based on the provided information, the most likely differential diagnosis (DDx) is the presence of a coagulation factor inhibitor. This means that the person's blood contains an inhibitor that is preventing normal blood clotting. The fact that the patient has normal PT (Prothrombin Time) but prolonged PTT (Partial Thromboplastin Time) supports this diagnosis. An impaired synthesis of a coagulation factor or endothelial dysfunction are less likely causes in this case. It would be important for the patient to further consult with a healthcare professional for a proper diagnosis and treatment.