Final answer:
The appendicular division of the skeleton facilitates movement and locomotion, involving the limbs and girdles that connect to the axial skeleton.
Step-by-step explanation:
One of the major functional differences between the appendicular and axial divisions is that the appendicular division is primarily responsible for facilitating movement and locomotion.
The appendicular skeleton includes all the bones of the arms, legs, hands, and feet, in addition to the shoulder and pelvic girdles that connect the limbs to the axial skeleton. This system is essential for the movement of the appendages and plays a role in protecting major organs involved in digestion, excretion, and reproduction.