Final answer:
James Madison enforced Macon's Bill Number 2 after its approval by Congress, which led to trade with France but continued harassment by Britain. This, along with domestic pressure, pushed Madison to request a declaration of war against Britain in 1812.
Step-by-step explanation:
When Macon's Bill Number 2 was enacted on May 1, 1810, President James Madison was reluctantly compelled to follow its terms. Despite Madison’s personal dislike for the bill, France, under Napoleon Bonaparte, was quick to respond and meet its conditions, which were to recognize American neutrality and cease attacks on American ships. The British, however, continued to harass American shipping, leading to intensified pressure on Madison. Ultimately, this pressure and the failure of Macon's Bill Number 2 to protect American interests pushed Madison towards requesting a declaration of war against Britain on June 1, 1812. This request was approved by Congress, initiating what is known as the War of 1812.