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What are the 4 factors that affect the number of myosin crossbridges?

User Cgaldiolo
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Final answer:

The number of myosin crossbridges, which determines muscle fiber tension, is influenced by sarcomere length, calcium ion concentration, neuromuscular junction activity, and muscle fiber recruitment.

Step-by-step explanation:

The number of myosin crossbridges is a crucial factor in muscle contraction and affects the amount of tension a muscle fiber can produce. Four primary factors influence the formation of myosin crossbridges:

Sarcomere length: Optimal overlap between actin and myosin filaments allows for maximum crossbridge formation.

Calcium ion concentration: Calcium binds to troponin, moving tropomyosin away from binding sites on actin, which is necessary for crossbridge cycling.

Neuromuscular junction activity: Acetylcholine (ACh) release triggers a cascade that culminates in muscle contraction.

Muscle fiber recruitment: The number and size of motor units activated and the frequency of action potentials can affect force production.

When these factors are optimal, a muscle can contract effectively, producing significant tension through efficient crossbridge formation and cycling, as represented in the sliding filament model of muscle contraction.

User Kaiak
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