Final answer:
An absolute contraindication of tissue plasminogen activator (t-PA) refers to a condition where t-PA should not be administered. Active internal bleeding or conditions that pose a high risk for bleeding are significant absolute contraindications to t-PA use. Other examples include a history of intracranial hemorrhage and recent brain surgery or trauma.
Step-by-step explanation:
An absolute contraindication of tissue plasminogen activator (t-PA) refers to a situation where the administration of this medication is strictly prohibited due to the high risk of serious or life-threatening complications. Tissue plasminogen activator is a thrombolytic agent used to dissolve blood clots and is commonly administered in cases of acute ischemic stroke, pulmonary embolism, and myocardial infarction.
One of the most critical absolute contraindications is active internal bleeding or a condition predisposing to such bleeding, including bleeding disorders. Other absolute contraindications include a history of intracranial hemorrhage, recent (within three months) intracranial or intraspinal surgery or trauma, presence of an intracranial neoplasm, arteriovenous malformation, or aneurysm, and severe uncontrolled hypertension.