Final answer:
MMPs have an important role in tumor invasion and metastasis, which is why they are targeted in the design of specific drug delivery systems that increase treatment efficacy and reduce side effects.
Step-by-step explanation:
Matrix metalloproteinases (MMPs) play a vital role in the development and progression of cancer, which directly connects to their potential usage in medical treatments. The up-regulation of MMP2 and MMP9 is commonly associated with the invasion, progression, and metastasis of many human tumors. This character can be leveraged to design targeted drug delivery systems.
For example, Zhu introduced a multifunctional complex drug delivery system that can selectively deliver drugs to tumor sites by responding to the up-regulated MMP2 in the tumor microenvironment. This strategy enhances the efficacy of treatment by improving the specificity and targetability of cancer therapeutics, thereby minimizing side effects on healthy tissues.